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KMID : 0525720140190010029
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Journal of Chitin and Chitosan
2014 Volume.19 No. 1 p.29 ~ p.33
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Biological Research of PEGylated Oligopeptide
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Kim Bo-Mi
Song Mi-Seon
Kang Kyung-Hee
Lee Duck-Hee
Chai Kyu-Yun
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Abstract
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PEGylated peptide (GHK and GPHyp), the collagen peptides with hydrophilic mPEG to improve stability, soubility, and degree of absorbance in physiology condition, were successfully synthesized in solid phase by coupling reactions through three steps. Their applications as cosmetic materials to improve the skin absorbablity will be evaluated. Acrylonitrile using mPEG ishydrolysis to yield the stylized oxide, which was separated by using Sephadex ion exchange chromatography. The good result from bioactive experiments of the effects on cytotoyicity, collagen activation and antioxidant were obtained.
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KEYWORD
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Peptide, SPPS, PEGylation, Cosmetics
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